Sarcoplasmic reticulum Ca 2+ , Mg 2+ , K + , and Cl − concentrations adjust quickly as heart rate changes
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چکیده
منابع مشابه
Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure
Heart function vitally relies on precisely controlled intracellular Ca homeostasis during each cardiac cycle. Abnormalities in Ca regulation cause contractile dysfunction and arrhythmias under different pathological conditions including heart failure (HF). Playing a particularly important role in heart contraction is the sarcoplasmic reticulum (SR). In adult ventricular myocytes, the SR forms a...
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The conformational states of Ca2+-ATPase in sarcoplasmic reticulum (SR) vesicles with or without a thousand-fold transmembrane Ca 2§ gradient have been studied by fluorescence spectroscopy and fluorescence quenching. In consequence of the establishment of the transmembrane Ca 2-gradient, the steady-state fluorescence results revealed a reproducible 8% decrease in the intrinsic fluorescence whil...
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Efforts to examine the relevant mechanisms involved in skeletal muscle fatigue are focusing on Ca(2+) handling within the active muscle cell. It has been demonstrated time and again that reductions in sarcoplasmic reticulum (SR) Ca(2+) release resulting from increased or intense muscle contraction will compromise tension development. This review seeks to accomplish two related goals: 1) to prov...
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Free [Ca ] inside the sarcoplasmic reticulum ([Ca ]SR) is difficult to measure yet critically important in controlling many cellular systems. In cardiac myocytes, [Ca ]SR regulates cardiac contractility. We directly measure [Ca ]SR in intact cardiac myocytes dynamically and quantitatively during beats, with high spatial resolution. Diastolic [Ca ]SR (1 to 1.5 mmol/L) is only partially depleted ...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2017
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2016.10.018